Active substances: Norfloxacin
A variety of antibiotics and regimens have been proposed with CDC recommending the combination of doxycycline plus rifampin for 3 weeks 191.
High risk exposure included direct exposure to brucellae such as sniffing bacteriologic cultures, direct skin contact, pipetting by mouth, inoculation or spraying into eyes, nose or mouth or exposure to aerosols outside a level 3 containment cabinet 40.
C hronic Brucellosis Perhaps no aspect of brucellosis engenders more controversy than chronic illness. The problem is not whether the condition exists, but rather obtaining a consensus on a definition and how to make the diagnosis.
Spink and associates showed that the majority of patients with brucellosis recovered within 12 months of receiving antimicrobial chemotherapy, but some patients continued to have clinical manifestations 181.
Those patients with clinical complaints for greater than 12 months could be divided into those with objective signs of infection, such as elevated levels of antibodies and focal disease, and those lacking objective signs of disease whose complaints resembled the chronic fatigue syndrome 182.
Patients with objective signs of infection, like patients with relapse, benefit from additional specific therapy, whereas those lacking objective signs of infection do not.
In addition to objective signs of disease, patients with chronic infection, like patients with relapsing brucellosis have persistently elevated levels of IgG antibodies in their serum 21. DNA in their serum and some remain asymptomatic while others have symptoms typical of chronic brucellosis 38.
In vitro antibiotic susceptibility testing of Brucella isolates from Egypt between 1999 and and evidence of probable rifampin resistance.
Ann Clin Microbiol Antimicrobials; Failure of short antimicrobial treatments for human brucellosis. Antimicrob Agents Chemother 19 -2.It licensed use in acute and chronic complicated kidney infections has been. Medical uses The initial approval by the U withdrawn as a result.
Vasculopathic changes in the cerebral arterial system with neurobrucellosis. Am J Neuroradiol.
In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs.
Antimicrob Agents Chemother 19 -1300. Doxyxycline plus streptomycin versus ciprofloxacin plus rifampicin in spinal brucellosis. BMC Infect Dis;6:72.